Rheumatoid Arthritis and Gastroduodenal Damage (Retrospective Analysis)

Background: Assessment of progress and process in Rheumatoid Arthritis (RA) and Gastroduodenal Damage (GDD) control at the population level is increasingly important. Rheumatoid arthritis is an autoimmune disease of unknown etiology. We aimed to investigate coherence between RA and pathology of Gastroduodenal Zone (GDZ) and shown development of GDZ pathology cause of use Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) for treating RA.

Methods: The work focused on identifying, among patients newly presenting with undifferentiated inflammatory synovitis, factors that best discriminated between those who were and those who were not at high risk for persistent and/or erosive disease—this being the appropriate current paradigm the disease construct “rheumatoid arthritis” and “gastroduodenal damage” [1,2,3]. In this article, it based on a retrospective analysis of case histories of patients with RA, data research pathology GDD to the extent of disease activity, duration of history and the failure of the joints, as well as the characteristics of ongoing pharmacotherapy.

Results: The results show that the pathology GDD in RA patients are often, in every fifth patient is a concomitant disease, and every tenth - is manifested in the form of clinical symptoms, the main causes of gastroduodenal lesions are viscera, long-term course of the disease and the frequent use of NSAIDs and corticosteroids. Among the patients 567 were women (90.7%), men - 58 (9.3%), i.e. in a ratio of 9.8: 1.0.

Conclusion: This new retrospective analysis shown that the pathology of Gastroduodenal Zone (GDZ) in patients with RA is quite common; every third patient has the symptoms of GDZ. Moreover, the main causes of gastroduodenal damage during RA are visceral, a long-term course of the disease, and the frequent use of NSAIDs and glucocorticosteroids (GCs).