Cytotoxic and Anticancer Activities of Indoline-2,3-dione (Isatin) and Its Derivatives

Ibrahim, Sulayman and Elsaman, Tilal (2018) Cytotoxic and Anticancer Activities of Indoline-2,3-dione (Isatin) and Its Derivatives. Journal of Pharmaceutical Research International, 21 (2). pp. 1-19. ISSN 24569119

[thumbnail of Elsaman2122018JPRI39708.pdf] Text
Elsaman2122018JPRI39708.pdf - Published Version

Download (537kB)

Abstract

Isatin (1H-indolin-2,3-dione) is a versatile bioactive and heterocyclic scaffold with an indole nucleus. For the past decades, isatin and its derivatives have shown tremendous interest among researchers (organic and medicinal chemists). Hence, their extensive structural modification has result in different analogues of isatin depicting wide range of biological and pharmacological activities including antimicrobial, anticancer, anti-inflammatory and analgesic, anticonvulsant, anti-viral, anti HIV and antiplasmodial activity. In this present review, we focus on isatin and its derivatives possessing cytotoxic and anticancer activity against different cancer cell lines from the period 2002 to 2015.

Item Type: Article
Subjects: GO for STM > Medical Science
Depositing User: Unnamed user with email support@goforstm.com
Date Deposited: 09 May 2023 06:29
Last Modified: 25 Jan 2024 03:50
URI: http://archive.article4submit.com/id/eprint/714

Actions (login required)

View Item
View Item