Mohammed, M. and Danmallam, A. and Kolo, M. T. and Abubakar, A. A. and Babakano, M. and Jajere, U. M. (2019) Preliminary Phytochemical Screening and Gastrointestinal Study on the Leaf Extract of Stachytarpheta angustifolia Mill Vahl (Verbenaceae) in Rabbit Jejunum. Journal of Pharmaceutical Research International, 26 (4). pp. 1-9. ISSN 2456-9119
Mohammed2642016JPRI26215.pdf - Published Version
Download (787kB)
Abstract
angustifolia (Verbenaceae) is mostly prescribed by the folkloric healers for various gastrointestinal disorders. This study was carried out to ascertain the gastrointestinal effect of the ethanol leaf extract and other various fractions (CHCl3, EtOAc, n- BuOH and residual aqueous) on rabbit Jejunum. The ethanol, n-butanol and residual aqueous of the extract exhibited dose concentration at (0.1, 0.2, 0.4 and 0.8 mg/ml) dependent contraction of the rabbit Jejunum which was blocked by atropine suggesting that the observed pharmacological actions was mediated through the muscarinic receptors. In contrast, chloroform and ethylacetate fraction of the leaf extract exhibit dose concentration dependent relaxation of the rabbit jejunum. Intreperitoneal LD50 of the extract in mice was found to be 295.8 mg/kg. Preliminary phytochemical screening of the leaf extract revealed the presence of carbohydrates, tannins, saponins, cardiac glycoside, sterols and terpenoids. The result indicated that, the plant extract possesses some pharmacological activity, hence justifying its use traditionally in alleviating gastrointestinal disorder.
Item Type: | Article |
---|---|
Subjects: | GO for STM > Medical Science |
Depositing User: | Unnamed user with email support@goforstm.com |
Date Deposited: | 28 Apr 2023 05:57 |
Last Modified: | 31 Jan 2024 03:58 |
URI: | http://archive.article4submit.com/id/eprint/571 |