Ozgen, Levent and Ozgen, Gülten (2022) Can early pregnancy decorin levels be a potential predictor for preterm birth? Pakistan Journal of Medical Sciences, 38 (8). ISSN 1682-024X
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Abstract
Objective: This study investigates the role of maternal decorin levels measured in the early second trimester of pregnancy in detecting the potential for preterm birth in late pregnancy.
Methods: The prospective, case-control study was carried out in tertiary university hospital from June to December 2021.Maternal serum samples were collected from 350 women aged 18–40 years with a singleton pregnancy during early second-trimester screening for aneuploidy, and stored at -80°C. All participants were followed up until delivery and 25 patients diagnosed with preterm birth group and 40 full-term healthy women were included in the study.
Results: The median maternal serum decorin level was 3.82 (1.15–12.37) ng/ml in the preterm birth (PTB) group and 4.63 (1.20–10.02) ng/ml in the control group, there was no statistically difference between the groups (p = 0.111). The mean gestational age was statistically significantly lower in the preterm birth group (33.1±2.7 weeks) than in the control (39±1.16 weeks) (p <0.001). The mean fetal weight was statistically significantly lower in the preterm birth group (2023.8±477 g) than in the control group (3309.7±353 g) (p <0.001).
Conclusion: Early second-trimester serum levels of decorin alone may not be a sufficiently accurate biomarker as a biochemical model for the prediction of preterm birth in asymptomatic women.
Item Type: | Article |
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Subjects: | GO for STM > Medical Science |
Depositing User: | Unnamed user with email support@goforstm.com |
Date Deposited: | 07 Apr 2023 07:59 |
Last Modified: | 02 Feb 2024 03:56 |
URI: | http://archive.article4submit.com/id/eprint/508 |