Can early pregnancy decorin levels be a potential predictor for preterm birth?

Ozgen, Levent and Ozgen, Gülten (2022) Can early pregnancy decorin levels be a potential predictor for preterm birth? Pakistan Journal of Medical Sciences, 38 (8). ISSN 1682-024X

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Abstract

Objective: This study investigates the role of maternal decorin levels measured in the early second trimester of pregnancy in detecting the potential for preterm birth in late pregnancy.

Methods: The prospective, case-control study was carried out in tertiary university hospital from June to December 2021.Maternal serum samples were collected from 350 women aged 18–40 years with a singleton pregnancy during early second-trimester screening for aneuploidy, and stored at -80°C. All participants were followed up until delivery and 25 patients diagnosed with preterm birth group and 40 full-term healthy women were included in the study.

Results: The median maternal serum decorin level was 3.82 (1.15–12.37) ng/ml in the preterm birth (PTB) group and 4.63 (1.20–10.02) ng/ml in the control group, there was no statistically difference between the groups (p = 0.111). The mean gestational age was statistically significantly lower in the preterm birth group (33.1±2.7 weeks) than in the control (39±1.16 weeks) (p <0.001). The mean fetal weight was statistically significantly lower in the preterm birth group (2023.8±477 g) than in the control group (3309.7±353 g) (p <0.001).

Conclusion: Early second-trimester serum levels of decorin alone may not be a sufficiently accurate biomarker as a biochemical model for the prediction of preterm birth in asymptomatic women.

Item Type: Article
Subjects: GO for STM > Medical Science
Depositing User: Unnamed user with email support@goforstm.com
Date Deposited: 07 Apr 2023 07:59
Last Modified: 02 Feb 2024 03:56
URI: http://archive.article4submit.com/id/eprint/508

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