Histological Evaluation of Intra-Articular Injections of Medical Ozone on the Repair of Experimentally Induced Articular Defects in Dogs

Damage to articular cartilage can eventually lead to osteoarthritis, a debilitating, degenerative joint disease. The limited natural healing ability of cartilage and the limitations of currently available therapies make treatment of cartilage defects a challenging. In recent years, interest has increased in the effects of medical ozone, which can be used safely inside the joint, and the ease of preparation has increased its use in vet clinics.

Aim: Aim of research, we investigated the utilization of medical ozone to treatment cartilage damage, the dogs were euthanized on day 56 after surgery. Histological assessments of the repair tissue were assessed for the treated and control defects at various times.

Methodology: Methodology ten healthy adult mongrel dogs were used in the current study, all animals underwent surgery to create a defect in the middle of the trochlear groove of the left femoral bone. The dogs were divided into two equal groups, Group I (control group) was left without treatment. While group II (O3 group) was treated by the injection of medical ozone.

Results: The result of the ozone group showed superior results in the cartilage development and reduction of the inflammatory process than control group, The cartilage appears to occupy in ozone group more than control group. the signs of mineralization occur in the peripheral portion, particularly in the edges near the trochlear groove in the ozone group.

Conclusion: Conclusion the process of injecting medical ozone into the joint affected by osteoarthritis has proven to be significantly effective compared to dogs that were left untreated. Therefore, we can go towards recommending the use of medical ozone as an effective and safe non-surgical treatment, continued for at least two months, in the treatment of severe osteoporosis.