SYNTHESIS, CHARACTERISATION AND ANTI-INFLAMMATORY PROPERTY OF HYDROXYCITRIC ACID MEDIATED ZINC NANOPARTICLES

Aim: To evaluate hydroxy citric acid mediated ZnNp and it’s anti-inflammatory and antioxidant effects.

Introduction: Hydroxy citric acid is a chemical that is found in fruit rinds of Garcinia cambogia, Garcinia indica, and Garcinia atroviridis, but very abundant in cambogia species. Hydroxy citric acid is used to improve exercise performance and weight loss. Zinc nanoparticles have a large surface area relative to their size and high catalytic activity. Hydroxycitric acid [HCA] is a derivative of citric acid that is found in a variety of tropical plants including Garcinia cambogia and Hibiscus sabdariffa. The use of HCA is contraindicated in patients suffering Colitis or Inflammatory Bowel Disease.

Materials and Methods: Biosynthesis and characterization of Hydroxycitric acid mediated Zinc Nanoparticle using Transmission Electron Microscope (TEM) and UV-vis spectroscopy, to evaluate its biological property Anti Inflammatory activity was analyzed by protein denaturation assay.

Results and Discussion: Hydroxycitric acid in zinc nanoparticles had a nanoparticle size ranging from 10-100 nm and it also showed a very good anti-inflammatory activity when compared with that of the standard anti-inflammatory drug.

Conclusion: The study concludes that hydroxy citric acid mediated in zinc nanoparticles shows a very good anti-inflammatory property and further research could be carried out for further investigations of hydroxy citric acid mediated in zinc nanoparticles in Pharmacology.