Pipeliner: A Nextflow-Based Framework for the Definition of Sequencing Data Processing Pipelines

Federico, Anthony and Karagiannis, Tanya and Karri, Kritika and Kishore, Dileep and Koga, Yusuke and Campbell, Joshua D. and Monti, Stefano (2019) Pipeliner: A Nextflow-Based Framework for the Definition of Sequencing Data Processing Pipelines. Frontiers in Genetics, 10. ISSN 1664-8021

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Abstract

The advent of high-throughput sequencing technologies has led to the need for flexible and user-friendly data preprocessing platforms. The Pipeliner framework provides an out-of-the-box solution for processing various types of sequencing data. It combines the Nextflow scripting language and Anaconda package manager to generate modular computational workflows. We have used Pipeliner to create several pipelines for sequencing data processing including bulk RNA-sequencing (RNA-seq), single-cell RNA-seq, as well as digital gene expression data. This report highlights the design methodology behind Pipeliner that enables the development of highly flexible and reproducible pipelines that are easy to extend and maintain on multiple computing environments. We also provide a quick start user guide demonstrating how to setup and execute available pipelines with toy datasets.

Item Type: Article
Subjects: GO for STM > Medical Science
Depositing User: Unnamed user with email support@goforstm.com
Date Deposited: 28 Feb 2023 09:06
Last Modified: 23 Dec 2023 05:21
URI: http://archive.article4submit.com/id/eprint/237

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