Study on Synthesis and Biologically Important of 2-Mercaptobenthiazole (MBT)-clubbed Chalcone Derivatives

In this present work base catalyzed method used for formation of chalcone of(E)-4-(3-(4-hydroxyphenyl)acryloyl)-5-methyl-2(p-tolyl)-1H-pyrazol-3(2H)-one (II) reacted with derivatives of S-benzo[d]thiol-2yl-2-chloroethanethioate (Ia-f) resulted in formation of corresponding derivatives of (E)-S-benzo[d]thiazol-2-yl 2-(4-(3-(5-methyl-3oxo-2(p-tolyl)-2,3-dihydro-1H-pyrazol-4-yl)-3-oxoprop-1-en-1-yl)phenoxy)etanethioate(IIIa-f) was confirmed by spectral characterization such as IR, 1H NMR, LC-MS and elemental analysis. The compounds were screened for their antimicrobial properties against a broad panel Gram-positive and Gram-negative bacteria as well as fungi. Compound 3c and 3e shows good activity. All the synthesized compounds were characterized by spectral data.