ANTIHYPERGLYCEMIC AND ANTIOXIDANT ACTIVITY OF PRUNETIN IN STREPTOZOTOCIN-INDUCED DIABETIC NEPHROTOXIC RATS

In the present study, we evaluated the protective impacts of Prunetin (PRU; 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one / 5,4'-dihydroxy-7-methoxyisoflavone) altering plasma lipid peroxides and antioxidant in streptozotocin (STZ)-induced diabetic nephrotoxic (DN) rats. Wistar albino rats were given a single intraperitoneal (i.p) dosage of 45 mg/kg of STZ to cause diabetic nephropathy, which was then treated with Group-III, an effective dose of prunetin of 80 mg/kg. We examined the levels of body weight, blood glucose, insulin, lipid peroxidation products, and antioxidants in experimental rats. In STZ -induced diabetic rats, we observed an increased blood glucose level and reduced levels of insulin as compared to control rats. Whereas prunetin administration to diabetic nephrotoxic-induced rats resulted in significantly lower blood glucose level and increased the insulin levels as compared to DN rats. In diabetic nephrotoxic rats, prunetin treatment enhanced the antioxidant enzymes activity in the liver and renal tissues. Overall, the finding suggests that prunetin have significant an antioxidant and hypoglycemic activity in STZ-induced Wistar rats by scavenging free radicals thereby reducing the risk of diabetic complecations.