The Antibacterial Activity of 2-aminoindanbiguanide Chloride and Acetate Salts against Resistant Gram-negative Bacilli

Antiseptics and disinfectants are important substances for medical care. However, the needs for new antiseptics have increased in the last few years, due to multi-drug resistant pathogens. In this study we aimed to evaluate, the efficacy of 2-aminoindanbiguanide chloride (2-AIB.HCI) and 2-aminoindanbiguanideacetate (2-AIB.HOAc) salts that were synthesized against multi-drug resistant Gram-negative bacilli (MDR-GNB) (Acinetobacter spp, Escherichia coli and Klebsiella pneumoniae). According to our resultsat70 mg/mL concentrations of 2-AIB.HCI and 2-AIB.HOAc salts have been confirmed to be effective against hospital infection causing MDR-GNB. It was shown that 2-AIB.HCI and 2-AIB.HOAc salts have antibacterial efficacy against MDR-GNB.