Can Prophylactic High Flow of Humidified and Warmed Filtered Air Improve Survival from Bacterial Pneumonia and SARS-CoV-2 in Elderly Individuals? The Role of Surfactant Protein A

Abbasi, Ata and Phelps, David S. and Ravi, Radhika and Floros, Joanna (2021) Can Prophylactic High Flow of Humidified and Warmed Filtered Air Improve Survival from Bacterial Pneumonia and SARS-CoV-2 in Elderly Individuals? The Role of Surfactant Protein A. Antioxidants, 10 (5). p. 640. ISSN 2076-3921

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Abstract

In this opinion article, we discuss a serendipitous observation we made in a study investigating survival in aged mice after bacterial infection. This observation involved a non-invasive ventilation approach that led to variable and higher survival in male and female mice with different genetic backgrounds for the innate immune molecule, surfactant protein A (SP-A). We suggest that employing the best ventilatory modality, whether that be HFNC or another method, may augment the role of other factors such as SP-A genetics and sex in a personalized approach, and may ultimately improve the outcome.

Item Type: Article
Subjects: GO for STM > Agricultural and Food Science
Depositing User: Unnamed user with email support@goforstm.com
Date Deposited: 04 Oct 2023 04:13
Last Modified: 04 Oct 2023 04:13
URI: http://archive.article4submit.com/id/eprint/1349

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