Development of Water-Insoluble Vehicle Comprising Natural Cyclodextrin—Vitamin E Complex

Ogawa, Shigesaburo and Shinkawa, Mai and Hirase, Ryuji and Tsubomura, Taro and Iuchi, Katsuya and Hara, Setsuko (2021) Development of Water-Insoluble Vehicle Comprising Natural Cyclodextrin—Vitamin E Complex. Antioxidants, 10 (3). p. 490. ISSN 2076-3921

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Abstract

Development of a novel antioxidant-delivery vehicle exerting biosafety has been attracting a great deal of interest. In this study, a vehicle comprising a natural composite consisting of vitamin E (α-tocopherol; Toc) and cyclodextrin (CD) additives was developed, directed toward aqua-related biological applications. Not only β-CD, but also γ-CD, tended to form a water-insoluble aggregate with Toc in aqueous media. The aggregated vehicle, in particular the γ-CD-added system, showed a remarkable sustained effect because of slow dynamics. Furthermore, a prominent cytoprotective effect by the γ-CD–Toc vehicle under the oxidative stress condition was confirmed. Thus, the novel vitamin E vehicle motif using γ-CD as a stabilizer was proposed, widening the usability of Toc for biological applications.

Item Type: Article
Subjects: GO for STM > Agricultural and Food Science
Depositing User: Unnamed user with email support@goforstm.com
Date Deposited: 13 Oct 2023 03:45
Last Modified: 13 Oct 2023 03:45
URI: http://archive.article4submit.com/id/eprint/1270

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