A Review on Traditional Plant Azadirachta indica: Natural Source for Disease Curability and Health Promotion

Neem (Azadirachta indica) is a medicinal plant, mostly found in the Himalayan region. The neem leaf is commonly and historically used in medicine to treat a variety of illnesses such as eye disorders, nose bleeding, loss of appetite and liver problems etc. Because of its various pharmacological and therapeutic effects, it is included in the Ayurvedic pharmacopoeia. As a result, this review provides current information on ethno-medicinal uses, phytochemistry, pharmacological effects, adverse effects of Azadirachta indica with future advancement. Several references were checked for identification, in-depth literature including online databases, documents, and blogs. Around 29% of the compounds in Azadirachta indica have been isolated and characterised. The limonoids in the neem tree have a wide variety of antimicrobial and insecticidal properties. Complex azadirachtin, salanin are active principles extracted from neem seed. These metabolites' biochemical pathways in the neem tree are completely unknown. Citrus sinensis is related to the neem tree phylogenetically. 62 percent of neem genomic was anchored into citrus chromosomes according to comparative study. The azadirachtin, nimbin, salanin and nimbidin from neem tissues were quantified by using LC-MS. This paper shows the various use of neem in different disorder.